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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Salinas, Royber | RP | Bowie Baysox | 24 | 04/10/2001 | Guarenas | VEN | Right | Right | 6' 3" | 205 lbs | - |
| Sanchez, Adan | C | Altoona Curve | 20 | 05/24/2005 | Panama | PAN | Right | Right | 6' 0" | 205 lbs | - |
| Sanchez, Emilio | SS | Akron RubberDucks | 18 | 04/13/2007 | Santo Domingo | DOM | Left | Right | 6' 1" | 160 lbs | - |
| Sanchez, Jordan | LF | Akron RubberDucks | 19 | 10/09/2005 | Matanzas | CUB | Left | Left | 6' 1" | 175 lbs | - |
| Sanchez, Sixto | SP | Free Agent | 27 | 07/29/1998 | San Cristóbal | DOM | Right | Right | 6' 0" | 235 lbs | - |
| Sanders, Will | SP | Hartford Yard Goats | 23 | 03/30/2002 | Atlanta | USA | Left | Right | 6' 6" | 230 lbs | - |
| Sanford, Wyatt | 2B | Richmond Flying Squirrels | 19 | 11/24/2005 | Frisco | USA | Left | Right | 6' 1" | 175 lbs | - |
| Sanquintin, Junior | SS | Free Agent | 23 | 01/08/2002 | Baní | DOM | Switch | Right | 6' 0" | 185 lbs | - |
| Santana, Adrian | SS | Akron RubberDucks | 20 | 07/18/2005 | Miami | USA | Switch | Right | 5' 11" | 160 lbs | - |
| Santos, Antonio | SP | Altoona Curve | 28 | 10/06/1996 | Villa Gonzalez | DOM | Right | Right | 6' 3" | 225 lbs | - |
| Saucke II, Casey | RF | Somerset Patriots | 22 | 07/24/2003 | Rochester | USA | Right | Right | 6' 3" | 210 lbs | - |
| Scarborough, Caden | RP | Bowie Baysox | 20 | 04/01/2005 | St. Cloud | USA | Right | Right | 6' 5" | 185 lbs | - |
| Schrock, Max | 2B | Altoona Curve | 30 | 10/12/1994 | Tacoma | USA | Left | Right | 5' 9" | 185 lbs | - |
| Schwartz, JT | 1B | Richmond Flying Squirrels | 25 | 12/17/1999 | Corona | USA | Left | Right | 6' 4" | 215 lbs | - |
| Scott, Connor | RF | Binghamton Rumble Ponies | 25 | 10/08/1999 | Tampa | USA | Left | Left | 6' 4" | 180 lbs | - |
| Seabold, Connor | SP | Portland Sea Dogs | 29 | 01/24/1996 | Laguna Hills | USA | Right | Right | 6' 2" | 190 lbs | - |
| Seise, Chris | SS | Binghamton Rumble Ponies | 26 | 01/06/1999 | Winter Garden | USA | Right | Right | 6' 2" | 175 lbs | - |
| Seminaris, Adam | SP | Akron RubberDucks | 26 | 10/19/1998 | Chino Hills | USA | Right | Left | 6' 0" | 190 lbs | - |
| Sequera, Manuel | 2B | Reading Fightin Phils | 23 | 09/28/2002 | Barquisimeto | VEN | Right | Right | 6' 1" | 170 lbs | - |
| Severino, Jhonny | 3B | Richmond Flying Squirrels | 20 | 11/08/2004 | Santo Domingo | DOM | Right | Right | 6' 3" | 185 lbs | - |
| Simpson, Will | 1B | Hartford Yard Goats | 24 | 08/28/2001 | Sammamish | USA | Right | Right | 6' 3" | 225 lbs | - |
| Smith, Caleb | SP | Free Agent | 34 | 07/28/1991 | Huntsville | USA | Right | Left | 6' 2" | 205 lbs | - |
| Smith, Jake | RP | Somerset Patriots | 26 | 10/04/1999 | Chapel Hill | USA | Right | Right | 6' 4" | 190 lbs | - |
| Smith, Tristan | RP | Harrisburg Senators | 22 | 05/25/2003 | Chesnee | USA | Right | Left | 6' 2" | 200 lbs | - |
| Snelling, Robby | SP | Akron RubberDucks | 21 | 12/19/2003 | Reno | USA | Right | Left | 6' 3" | 210 lbs | - |
| Snyder, Trey | SS | Altoona Curve | 20 | 09/21/2005 | Kearney | USA | Right | Right | 6' 1" | 195 lbs | - |
| Soderstrom, Tyler | C | Altoona Curve | 23 | 11/24/2001 | Turlock | USA | Left | Right | 6' 2" | 200 lbs | - |
| Solometo, Anthony | SP | Harrisburg Senators | 22 | 12/02/2002 | Winslow Township | USA | Left | Left | 6' 5" | 220 lbs | - |
| Spikes, Ryan | 3B | Altoona Curve | 22 | 03/13/2003 | Covington | USA | Right | Right | 5' 9" | 180 lbs | - |
| Sprinkle, Jordan | SS | Akron RubberDucks | 24 | 03/06/2001 | Indio | USA | Right | Right | 5' 10" | 170 lbs | - |
| Stephen, Khal | RP | Bowie Baysox | 22 | 12/21/2002 | Williamsport | USA | Right | Right | 6' 4" | 215 lbs | - |
| Stoudt, Levi | SP | Hartford Yard Goats | 27 | 12/04/1997 | Pottstown | USA | Right | Right | 6' 1" | 195 lbs | $570,500 |
| Stovall, Peyton | 1B | Richmond Flying Squirrels | 22 | 02/14/2003 | Haughton | USA | Left | Right | 6' 0" | 185 lbs | - |
| Strotman, Drew | SP | New Hampshire Fisher Cats | 29 | 09/03/1996 | Sunnyvale | USA | Right | Right | 6' 3" | 195 lbs | - |
| Suarez, Santiago | SP | Harrisburg Senators | 20 | 01/11/2005 | Cumana | VEN | Right | Right | 6' 2" | 175 lbs | - |
| Suero, Estuar | LF | Reading Fightin Phils | 20 | 08/29/2005 | San Pedro de Macorís | DOM | Switch | Right | 6' 5" | 180 lbs | - |
| Sullivan, Cameron | RP | Reading Fightin Phils | 19 | 03/22/2006 | Indianapolis | USA | Right | Right | 6' 2" | 200 lbs | - |
| Susac, Daniel | C | Portland Sea Dogs | 24 | 05/14/2001 | Roseville | USA | Right | Right | 6' 4" | 220 lbs | - |
| Sweet, Devin | RP | New Hampshire Fisher Cats | 29 | 09/06/1996 | Greensboro | USA | Switch | Right | 5' 11" | 185 lbs | $570,500 |
