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| Wednesday, September 24th , 2025 |
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| RP Jace Fry (AA Portland) retired from professional baseball. |
| RP Lucas Gilbreath (AA Portland) retired from professional baseball. |
| RP Brendon Little (AA Portland) retired from professional baseball. |
| 2B Jonathan Arauz (AA Portland) retired from professional baseball. |
| RP Yerry De Los Santos (AA Portland) retired from professional baseball. |
| RP Luis Escobar (AA Portland) retired from professional baseball. |
| RP Ronald Bolanos (AA Portland) retired from professional baseball. |
| RP Andrew Bellatti (AA Portland) retired from professional baseball. |
| Friday, September 19th , 2025 |
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| Placed 2B Edwin Arroyo on the Double-A Northeast 7-day injured list, retroactive to 09/18/2025. |
| Monday, August 25th , 2025 |
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| Placed SP Ronald Bolanos on the Double-A Northeast 7-day injured list, retroactive to 08/24/2025. |
| Sunday, August 24th , 2025 |
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| Placed C Henry Davis on the Triple-A East 7-day injured list, retroactive to 08/23/2025. |
| Tuesday, August 19th , 2025 |
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| Placed RP Tanner Witt on the Double-A Northeast 7-day injured list, retroactive to 08/18/2025. |
| Tuesday, August 5th , 2025 |
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| Placed C Henry Davis on the Triple-A East 7-day injured list, retroactive to 08/04/2025. |
| Monday, July 14th , 2025 |
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| Placed 2B Vidal Bruján on the Triple-A East 7-day injured list, retroactive to 07/13/2025. |
| Friday, June 27th , 2025 |
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| Placed LF Akil Baddoo on the Triple-A East 7-day injured list, retroactive to 06/26/2025. |
| Monday, June 23rd , 2025 |
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| Placed RP Thomas White on the Double-A Northeast 7-day injured list, retroactive to 06/22/2025. |
| Sunday, May 25th , 2025 |
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| Placed C Henry Davis on the Triple-A East 7-day injured list, retroactive to 05/24/2025. |
| Thursday, May 15th , 2025 |
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| Placed 3B Gabriel Arias on the Triple-A East 7-day injured list, retroactive to 05/14/2025. |
| Placed RP Trevor Harrison on the Double-A Northeast 7-day injured list, retroactive to 05/14/2025. |
| Wednesday, May 14th , 2025 |
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| Placed RP Thomas White on the Double-A Northeast 7-day injured list, retroactive to 05/13/2025. |
| Tuesday, March 18th , 2025 |
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| Placed SP Jameson Taillon on the secondary (40-man) roster. |
| Placed CF Mike Trout on the secondary (40-man) roster. |
| Placed SP Zack Wheeler on the secondary (40-man) roster. |
| Placed LF Alex Verdugo on the secondary (40-man) roster. |
| Placed SS Javier Baez on the secondary (40-man) roster. |
| Placed SP Lucas Giolito on the secondary (40-man) roster. |
| Placed RP Jared Koenig on the secondary (40-man) roster. |
| Placed 2B Richie Palacios on the secondary (40-man) roster. |
| Placed 2B Jorge Polanco on the secondary (40-man) roster. |
| Tuesday, February 11th , 2025 |
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| Purchased the contract of SP Joey Cantillo from Triple A Worcester. |
| Purchased the contract of SP Ryne Nelson from Triple A Worcester. |
| Purchased the contract of 2B Vidal Bruján from Triple A Worcester. |
| Purchased the contract of C Henry Davis from Triple A Worcester. |
| Purchased the contract of SP Cole Wilcox from Triple A Worcester. |
| Purchased the contract of RP Hans Crouse from Triple A Worcester. |
| Purchased the contract of C Blake Hunt from Triple A Worcester. |
| Purchased the contract of CL Carmen Mlodzinski from Triple A Worcester. |
