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| Wednesday, June 4th , 2025 |
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| Philadelphia Phillies: Sent SP Miles Mikolas to Triple A Lehigh Valley for injury rehab. |
| The Kansas City Royals traded 30-year old RHP Walker Buehler and 26-year old RHP Brusdar Graterol to the Miami Marlins, getting 18-year old minor league RF Paulino Santana and 25-year old minor league RHP Shane Baz in return. |
| The Kansas City Royals traded 35-year old LHP Danny Coulombe and 36-year old RHP Liam Hendriks to the Cleveland Guardians, getting 18-year old minor league RF Victor Hurtado in return. |
| Baltimore Orioles: Sent SP Nathan Eovaldi to Triple A Norfolk for injury rehab. |
| Baltimore Orioles: Sent SP Packy Naughton to Triple A Norfolk for injury rehab. |
| Baltimore Orioles: Sent SP Bryce Elder to Triple A Norfolk for injury rehab. |
| Baltimore Orioles: Placed CL Jeff Hoffman on the 15-day injured list, retroactive to 06/01/2025. |
| Chicago White Sox: Placed RP Jordan Romano on the 15-day injured list, retroactive to 06/03/2025. |
| Cleveland Guardians: RP Aaron Loup was designated for assignment and placed on waivers. |
| Cleveland Guardians: Placed RP Liam Hendriks on the active roster. |
| Cleveland Guardians: RP Ryan Weber was designated for assignment and placed on waivers. |
| Cleveland Guardians: Placed RP Danny Coulombe on the active roster. |
| Los Angeles Dodgers: Placed 1B Brandon Belt on the 10-day injured list, retroactive to 06/01/2025. |
| Miami Marlins: Transferred C Jose Herrera to the 60-day IL. |
| Miami Marlins: Placed RP Brusdar Graterol on the active roster. |
| Miami Marlins: Placed SP Walker Buehler on the active roster. |
| Seattle Mariners: LF Connor Joe was designated for assignment and placed on waivers. |
| Los Angeles Dodgers: RP Jay Groome was designated for assignment and placed on waivers. |
| Miami Marlins: CF Korry Howell was designated for assignment and placed on waivers. |
| Pittsburgh Pirates: RP Yerry Rodriguez was designated for assignment and placed on waivers. |
| Los Angeles Dodgers: 3B Davis Wendzel was designated for assignment and placed on waivers. |
| Los Angeles Dodgers: RP Sam Moll was designated for assignment and placed on waivers. |
| Los Angeles Dodgers: SP Griffin Canning was designated for assignment and placed on waivers. |
| Houston Astros: RP Brandon Hughes was designated for assignment and placed on waivers. |
| New York Yankees: RP Ryan Garcia was designated for assignment and placed on waivers. |
| Cleveland Guardians: RP Hector Neris was designated for assignment and placed on waivers. |
| Cleveland Guardians: RP Richard Bleier was designated for assignment and placed on waivers. |
| Colorado Rockies: Placed C Cal Raleigh on the active roster. |
| Colorado Rockies: Activated C Cal Raleigh from the injured list. |
| New York Mets: Placed CF Myles Straw on the active roster. |
| New York Mets: Activated CF Myles Straw from the injured list. |
| St. Louis Cardinals: Placed SP Martin Perez on the 15-day injured list, retroactive to 06/01/2025. |
| St. Louis Cardinals: Sent RP David Robertson to Triple A Memphis for injury rehab. |
| Sunday, June 1st , 2025 |
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| Houston Astros: Placed SS Austin Gauthier on the 10-day injured list, retroactive to 05/29/2025. |
| Texas Rangers: Placed 1B Alex Kirilloff on the 10-day injured list, retroactive to 05/29/2025. |
| Saturday, May 31st , 2025 |
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| Philadelphia Phillies: Placed SS Tyler Fitzgerald on the 10-day injured list, retroactive to 05/30/2025. |
| Thursday, May 29th , 2025 |
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| Philadelphia Phillies: Sent 1B Josh Bell to Triple A Lehigh Valley for injury rehab. |
| Tuesday, May 20th , 2025 |
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| Philadelphia Phillies: Placed 1B Josh Bell on the 10-day injured list, retroactive to 05/17/2025. |
| Philadelphia Phillies: Placed SP Miles Mikolas on the 15-day injured list, retroactive to 05/17/2025. |
| Wednesday, May 14th , 2025 |
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| Seattle Mariners: Placed C Elias Díaz on the 10-day injured list, retroactive to 05/11/2025. |
| Sunday, May 11th , 2025 |
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| Chicago Cubs: Placed LF Dane Myers on the active roster. |
| Chicago Cubs: Activated LF Dane Myers from the injured list. |
| Thursday, May 8th , 2025 |
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| New York Mets: Placed CF Myles Straw on the 10-day injured list, retroactive to 05/05/2025. |
| St. Louis Cardinals: Sent CF Quincy Hamilton to Triple A Memphis for injury rehab. |
| St. Louis Cardinals: Placed RP David Robertson on the 15-day injured list, retroactive to 05/07/2025. |
| Monday, May 5th , 2025 |
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| Chicago White Sox: Placed SP Zac Gallen on the active roster. |
| Chicago White Sox: Activated SP Zac Gallen from the injured list. |
| Sunday, April 20th , 2025 |
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| Baltimore Orioles: Placed SP Packy Naughton on the 15-day injured list, retroactive to 04/18/2025. |
| Baltimore Orioles: Placed SP Nathan Eovaldi on the 15-day injured list, retroactive to 04/18/2025. |
| Baltimore Orioles: Placed SP Bryce Elder on the 15-day injured list, retroactive to 04/18/2025. |
| Chicago White Sox: Placed SP Zac Gallen on the 15-day injured list, retroactive to 04/17/2025. |
| Colorado Rockies: Placed C Cal Raleigh on the 10-day injured list, retroactive to 04/19/2025. |
| Thursday, April 17th , 2025 |
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| St. Louis Cardinals: Sent CF Greg Allen to Triple A Memphis for injury rehab. |
| St. Louis Cardinals: Placed CF Quincy Hamilton on the 10-day injured list, retroactive to 04/14/2025. |
| Monday, April 14th , 2025 |
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| Minnesota Twins: Placed DH Ian Happ on the 10-day injured list, retroactive to 04/11/2025. |
| Tuesday, April 8th , 2025 |
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| Chicago Cubs: Placed LF Dane Myers on the 10-day injured list, retroactive to 04/07/2025. |
| Seattle Mariners: Designated 1B Connor Joe for assignment. |
| Wednesday, April 2nd , 2025 |
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| St. Louis Cardinals: Placed CF Greg Allen on the 10-day injured list, retroactive to 04/01/2025. |
| Tuesday, March 18th , 2025 |
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| San Francisco Giants: Designated RP Sean Hjelle for assignment. |
| New York Mets: Designated CF Derek Hill for assignment. |
| New York Mets: Released CF Derek Hill. |
| Tuesday, February 11th , 2025 |
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| Cincinnati Reds: Placed 3B Brett Baty on the active roster. |
| Cincinnati Reds: Placed RP Garrett Whitlock on the active roster. |
| Cincinnati Reds: Placed RP Alex Vesia on the active roster. |
| Los Angeles Dodgers: Placed SP Huascar Ynoa on the active roster. |
| Cincinnati Reds: LF Jordan Luplow was designated for assignment and placed on waivers. |
| New York Yankees: Designated RP Daulton Jefferies for assignment. |
| New York Yankees: Designated SP Sixto Sanchez for assignment. |
| San Diego Padres: Designated RP Xzavion Curry for assignment. |
| Texas Rangers: Designated RP Ryan Jensen for assignment. |
| Arizona Diamondbacks: Designated SS Delvin Perez for assignment. |
| Arizona Diamondbacks: Placed SS Delvin Perez on the active roster. |
| Cincinnati Reds: Placed RP Colin Poche on the active roster. |
| Los Angeles Dodgers: Placed RP Bryce Montes De Oca on the active roster. |
| Miami Marlins: Placed CF Korry Howell on the active roster. |
| New York Yankees: Placed 2B Taylor Walls on the active roster. |
| New York Yankees: Placed C Andrew Knizner on the active roster. |
| Oakland Athletics: Placed RP Ron Marinaccio on the active roster. |
| St. Louis Cardinals: Placed RP Chris Clarke on the active roster. |
| Texas Rangers: Placed RP Ryan Jensen on the active roster. |
| Texas Rangers: Placed RP Jayden Murray on the active roster. |
| Arizona Diamondbacks: Placed SS Delvin Perez on the active roster. |
