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| Monday, September 1st , 2025 |
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| Purchased the contract of RF Oscar Colas from Triple A Omaha. |
| Purchased the contract of SP Ryan Webb from Triple A Omaha. |
| Tuesday, August 19th , 2025 |
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| Placed CL Ryan Helsley on the active roster. |
| Activated CL Ryan Helsley from the injured list. |
| Friday, August 1st , 2025 |
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| Purchased the contract of LF Ivan Johnson from Triple A Omaha. |
| Purchased the contract of RP Davis Sharpe from Triple A Omaha. |
| Thursday, July 31st , 2025 |
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| Traded 29-year old SS Willy Adames and 37-year old 1B Paul Goldschmidt to the San Diego Padres, getting nothing in return. |
| Tuesday, July 29th , 2025 |
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| Placed RP Penn Murfee on the active roster. |
| Placed CL Ryan Helsley on the 15-day injured list, retroactive to 07/26/2025. |
| Wednesday, July 23rd , 2025 |
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| Traded 27-year old RHP Jhoan Duran to the Houston Astros, getting 18-year old minor league 3B Yairo Padilla and 31-year old RHP Penn Murfee in return. |
| Saturday, July 5th , 2025 |
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| Assigned SP Jack Leiter to Double A Northwest Arkansas. |
| Assigned C Dillon Dingler to Double A Northwest Arkansas. |
| Friday, July 4th , 2025 |
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| Purchased the contract of SP Taylor Dollard from Triple A Omaha. |
| Wednesday, June 25th , 2025 |
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| Traded 29-year old RHP Dylan Cease to the Cleveland Guardians, getting 25-year old minor league RHP Jack Leiter and 26-year old minor league C Dillon Dingler in return. |
| Friday, June 13th , 2025 |
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| Purchased the contract of SP Jake Wong from Double A Northwest Arkansas. |
| Purchased the contract of RF Nate Eaton from Triple A Omaha. |
| Tuesday, June 10th , 2025 |
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| Traded 28-year old 3B Rafael Devers to the New York Mets, getting 24-year old 1B Kyle Manzardo, 23-year old minor league RF Zac Veen, and 22-year old minor league 1B Blaze Jordan in return. |
| Traded 30-year old 1B Pete Alonso and 32-year old RHP Aaron Nola to the Philadelphia Phillies, getting 36-year old minor league RHP Miles Mikolas and 21-year old minor league SS Carson Williams in return. |
| Placed SP Miles Mikolas on the active roster. |
| Placed 1B Kyle Manzardo on the active roster. |
| Wednesday, June 4th , 2025 |
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| Traded 30-year old RHP Walker Buehler and 26-year old RHP Brusdar Graterol to the Miami Marlins, getting 18-year old minor league RF Paulino Santana and 25-year old minor league RHP Shane Baz in return. |
| Traded 35-year old LHP Danny Coulombe and 36-year old RHP Liam Hendriks to the Cleveland Guardians, getting 18-year old minor league RF Victor Hurtado in return. |
| Purchased the contract of SP Cody Poteet from Triple A Omaha. |
| Assigned SP Shane Baz to Triple A Omaha. |
| Purchased the contract of SP Luis Medina from Triple A Omaha. |
| Purchased the contract of RP Austin Adams from Double A Northwest Arkansas. |
| Tuesday, February 11th , 2025 |
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| Purchased the contract of SP José Soriano from Triple A Omaha. |
| Purchased the contract of CF Joey Wiemer from Triple A Omaha. |
| Purchased the contract of RF Oscar Colas from Triple A Omaha. |
| Purchased the contract of SP Luis Medina from Triple A Omaha. |
| Purchased the contract of CL Taylor Dollard from Triple A Omaha. |
| Purchased the contract of C Brett Sullivan from Triple A Omaha. |
| Purchased the contract of RF Elijah Dunham from Triple A Omaha. |
| Purchased the contract of RP Yosver Zulueta from Triple A Omaha. |
| Purchased the contract of RP Cole Winn from Triple A Omaha. |
| Purchased the contract of RP Ryan Webb from Triple A Omaha. |
| Purchased the contract of LF Jarred Kelenic from Triple A Omaha. |
| Invited non-roster SP Alek Manoah to Spring Training camp. |
| Invited non-roster SP Bruce Zimmermann to Spring Training camp. |
| Invited non-roster SP Jonathan Cannon to Spring Training camp. |
| Invited non-roster LF Jarred Kelenic to Spring Training camp. |
| Optioned RF Nate Eaton to Triple A Omaha. |
